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SREBP2 of LATSregulated nuclearcytoplasmic translocation

mice In  cells of from of tumor subcutaneous promoted hepatoma observed and SREBP2 LATS translocation in samples a subset as nuclear

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maintains signalling expression breast cancer and Hippo ER ER

cells deletion LATS12 activity tumor  with dKO were LAST12 MCF7 kinase or and injected wildtype mice Consistently and LATS YAPTAZ

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kinases the and LATS advanced stage regulate to transition SLUG

cells represented cells more SAS advanced than transcriptional cancer that the SASδ parental SLUG  suggesting EMTrelated factor mice

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